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Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P51993 |
| Other Accession | NP_001035791.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit Ig |
| Calculated MW | 41860 Da |
| Antigen Region | 20-49 aa |
| Gene ID | 2528 |
|---|---|
| Other Names | Alpha-(1, 3)-fucosyltransferase 6, Fucosyltransferase 6, Fucosyltransferase VI, Fuc-TVI, FucT-VI, Galactoside 3-L-fucosyltransferase, FUT6, FCT3A |
| Target/Specificity | This FUT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human FUT6. |
| Dilution | IHC-P~~1:10~50 WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FUT6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FUT6 |
|---|---|
| Synonyms | FCT3A |
| Function | Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates. |
| Cellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi |
| Tissue Location | Kidney, liver, colon, small intestine, bladder, uterus and salivary gland |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Stern, H.M., et al. Clin. Cancer Res. 16(5):1587-1596(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Norden, R., et al. Glycobiology 19(7):776-788(2009)
Higai, K., et al. Glycoconj. J. 25(3):225-235(2008)
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