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CDH19 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9H159 |
| Other Accession | NP_066976.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 87002 Da |
| Antigen Region | 613-640 aa |
| Gene ID | 28513 |
|---|---|
| Other Names | Cadherin-19, CDH19, CDH7L2 |
| Target/Specificity | This CDH19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-640 amino acids from the C-terminal region of human CDH19. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CDH19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDH19 |
|---|---|
| Synonyms | CDH7L2 |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in many tissues, with the exception of uterus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes.
References
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Kools, P., et al. Genomics 68(3):283-295(2000)
Shimoyama, Y., et al. Biochem. J. 349 (PT 1), 159-167 (2000) :
Kremmidiotis, G., et al. Genomics 49(3):467-471(1998)
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