|Application ||WB, IHC-P, E|
|Calculated MW||87002 Da|
|Antigen Region||613-640 aa|
|Other Names||Cadherin-19, CDH19, CDH7L2|
|Target/Specificity||This CDH19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-640 amino acids from the C-terminal region of human CDH19.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDH19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in many tissues, with the exception of uterus|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes.
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Kools, P., et al. Genomics 68(3):283-295(2000)
Shimoyama, Y., et al. Biochem. J. 349 (PT 1), 159-167 (2000) :
Kremmidiotis, G., et al. Genomics 49(3):467-471(1998)
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