|Application ||WB, E|
|Other Accession||Q07141, Q62441, NP_008936.2|
|Calculated MW||83755 Da|
|Antigen Region||167-196 aa|
|Other Names||Transducin-like enhancer protein 4, Grg-4, Groucho-related protein 4, TLE4, GRG4, KIAA1261|
|Target/Specificity||This TLE4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the N-terminal region of human TLE4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TLE4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).|
|Tissue Location||In all tissues examined, mostly in brain, and muscle|
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Provided below are standard protocols that you may find useful for product applications.
TLE4 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Liu, Y., et al. PLoS Genet. 5 (11), E1000707 (2009) :
Hancock, D.B., et al. PLoS Genet. 5 (8), E1000623 (2009) :
Stolk, L., et al. Nat. Genet. (2009) In press :
Dayyani, F., et al. Blood 111(8):4338-4347(2008)
Heimbucher, T., et al. Mol. Cell. Biol. 27(1):340-351(2007)
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