|Application ||WB, E|
|Other Accession||P10895, NP_001124436.1, NP_006216.2|
|Calculated MW||85665 Da|
|Antigen Region||134-163 aa|
|Other Names||1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase delta-1, Phosphoinositide phospholipase C-delta-1, Phospholipase C-III, PLC-III, Phospholipase C-delta-1, PLC-delta-1, PLCD1|
|Target/Specificity||This PLCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the N-terminal region of human PLCD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLCD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.|
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Provided below are standard protocols that you may find useful for product applications.
Phosphoinositide-specific phospholipase C (PLC) acts as a signal transducer that generates 2 second messengers, diacylglycerol and inositol 1,4,5-trisphosphate, by hydrolyzing inositol phospholipids. PLC comprises a diverse family of enzymes that differ in structure and tissue distribution (Berridge, 1993 [PubMed 8381210]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Guo, Y., et al. J. Biol. Chem. 285(32):24999-25008(2010)
Segat, L., et al. Vaccine 28(10):2201-2206(2010)
Godin, C.M., et al. Mol. Pharmacol. 77(3):388-395(2010)
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