|Application ||WB, E|
|Calculated MW||53542 Da|
|Antigen Region||366-395 aa|
|Other Names||Serine/arginine-rich splicing factor 11, Arginine-rich 54 kDa nuclear protein, p54, Splicing factor, arginine/serine-rich 11, SRSF11, SFRS11|
|Target/Specificity||This SFRS11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-395 amino acids from the C-terminal region of human SFRS11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SFRS11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function in pre-mRNA splicing.|
|Cellular Location||Nucleus. Note=Colocalizes with spliceosome components|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Manley, J.L., et al. Genes Dev. 24(11):1073-1074(2010)
Casado, P., et al. J Proteomics 71(6):592-600(2009)
Shepard, P.J., et al. Genome Biol. 10 (10), 242 (2009) :
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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