EAPP Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q56P03 |
Other Accession | NP_060923.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 32762 Da |
Antigen Region | 204-233 aa |
Gene ID | 55837 |
---|---|
Other Names | E2F-associated phosphoprotein, EAPP, EAPP, C14orf11 |
Target/Specificity | This EAPP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-233 amino acids from the C-terminal region of human EAPP. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | EAPP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EAPP |
---|---|
Synonyms | C14orf11 |
Function | May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. |
Cellular Location | Cytoplasm. Nucleus. |
Tissue Location | Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation.
References
Schwarzmayr, L., et al. Int. J. Biochem. Cell Biol. 40(12):2845-2853(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
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