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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MBTPS2 Antibody (N-term)   

MBTPS2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MBTPS2 Antibody (N-term) AP12972a
    MBTPS2 Antibody (N-term) (Cat. #AP12972a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the MBTPS2 antibody detected the MBTPS2 protein (arrow).
  • IHC-P - MBTPS2 Antibody (N-term) AP12972a
    MBTPS2 Antibody (N-term) (Cat. #AP12972a)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MBTPS2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O43462
Other Accession Q8CHX6, Q0III2, NP_056968.1
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57444 Da
Antigen Region 15-44 aa
Additional Information
Gene ID 51360
Other Names Membrane-bound transcription factor site-2 protease, Endopeptidase S2P, Sterol regulatory element-binding proteins intramembrane protease, SREBPs intramembrane protease, MBTPS2, S2P
Target/Specificity This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human MBTPS2.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMBTPS2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBTPS2
Synonyms S2P
Function Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.
Cellular Location Membrane; Multi-pass membrane protein Cytoplasm
Tissue Location Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas
Research Areas
Citations (0)

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Background

This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

References

Ming, A., et al. Pediatr Dermatol 26(4):427-431(2009)
Oeffner, F., et al. Am. J. Hum. Genet. 84(4):459-467(2009)
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Shen, J., et al. J. Biol. Chem. 279(41):43046-43051(2004)
Lee, K., et al. Genes Dev. 16(4):452-466(2002)

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$ 295.00
$ 99.00
Cat# AP12972a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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