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LRSAM1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - LRSAM1 Antibody (N-term) AP12973A
    LRSAM1 Antibody (N-term) (Cat. #AP12973a) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the LRSAM1 antibody detected the LRSAM1 protein (arrow).
  • IHC-P - LRSAM1 Antibody (N-term) AP12973A
    LRSAM1 Antibody (N-term) (Cat. #AP12973a)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LRSAM1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6UWE0
Other Accession Q80ZI6, NP_612370.3, NP_001177652.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 83594 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 90678
Other Names E3 ubiquitin-protein ligase LRSAM1, 632-, Leucine-rich repeat and sterile alpha motif-containing protein 1, Tsg101-associated ligase, hTAL, LRSAM1, TAL
Target/Specificity This LRSAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LRSAM1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLRSAM1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TAL
Function E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos.
Cellular Location Cytoplasm. Note=Displays a punctuate distribution and localizes to a submembranal ring
Tissue Location Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue
Research Areas
Citations (0)

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LRSAM1 is a multifunctional RING finger protein that selectively regulates cell adhesion molecules, has ubiquitin ligase activity, and plays a role in receptor endocytosis and viral budding (Li et al., 2003 [PubMed 14635195]; Amit et al., 2004 [PubMed 15256501]).


Markson, G., et al. Genome Res. 19(10):1905-1911(2009)
van Wijk, S.J., et al. Mol. Syst. Biol. 5, 295 (2009) :
McDonald, B., et al. Mol. Biol. Cell 19(2):754-763(2008)
Amit, I., et al. Genes Dev. 18(14):1737-1752(2004)
Li, B., et al. J. Cell. Biochem. 90(6):1224-1241(2003)

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Cat# AP12973A
(40 western blots)
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