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FPR3 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - FPR3 Antibody (C-term) AP12974b
    FPR3 Antibody (C-term) (Cat. #AP12974b) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the FPR3 antibody detected the FPR3 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P25089
Other Accession NP_002021.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 39965 Da
Antigen Region 322-351 aa
Additional Information
Gene ID 2359
Other Names N-formyl peptide receptor 3, FMLP-related receptor II, FMLP-R-II, Formyl peptide receptor-like 2, FPR3, FPRH1, FPRL2
Target/Specificity This FPR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-351 amino acids from the C-terminal region of human FPR3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFPR3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FPR3
Synonyms FPRH1, FPRL2
Function Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin (PubMed:15465011).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Detected in various tissues with highest expression in lung.
Research Areas
Citations (0)
citation

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Background

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

References

Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Kim, S.D., et al. J. Immunol. 183(9):5511-5517(2009)
Devosse, T., et al. J. Immunol. 182(8):4974-4984(2009)
Lambert, N.A. Sci Signal 1 (25), RE5 (2008) :
Lee, H.Y., et al. Biochem. Biophys. Res. Commun. 359(4):985-990(2007)

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$ 365.00
$ 140.00
Cat# AP12974b
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