|Application ||WB, IHC-P, E|
|Calculated MW||72153 Da|
|Antigen Region||602-631 aa|
|Other Names||Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+), Amino acid transporter ATB0+, Solute carrier family 6 member 14, SLC6A14|
|Target/Specificity||This SLC6A14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 602-631 amino acids from the C-terminal region of human SLC6A14.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC6A14 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Corpeleijn, E., et al. Obesity (Silver Spring) 18(7):1369-1377(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Anderson, C.M., et al. J. Physiol. (Lond.) 586 (PT 17), 4061-4067 (2008) :
Eriksson, A., et al. BMC Gastroenterol 8, 34 (2008) :
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