|Application ||WB, E|
|Calculated MW||34333 Da|
|Antigen Region||267-296 aa|
|Other Names||Taste receptor type 2 member 1, T2R1, Taste receptor family B member 7, TRB7, TAS2R1|
|Target/Specificity||This TAS2R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-296 amino acids from the C-terminal region of human TAS2R1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAS2R1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil.
Upadhyaya, J., et al. Biochem. Biophys. Res. Commun. 398(2):331-335(2010)
Weiss, L.A., et al. Nature 461(7265):802-808(2009)
Go, Y., et al. Genetics 170(1):313-326(2005)
Fischer, A., et al. Mol. Biol. Evol. 22(3):432-436(2005)
Zhang, Y., et al. Cell 112(3):293-301(2003)
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