|Application ||WB, IHC-P, E|
|Calculated MW||20266 Da|
|Antigen Region||33-61 aa|
|Other Names||NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4, Hormone-regulated proliferation-associated protein of 20 kDa, NDUFAF4, C6orf66, HRPAP20|
|Target/Specificity||This NDUFAF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human NDUFAF4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NDUFAF4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.|
|Cellular Location||Mitochondrion. Membrane; Lipid-anchor|
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Provided below are standard protocols that you may find useful for product applications.
NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene are a cause of mitochondrial complex I deficiency. [provided by RefSeq].
Saada, A., et al. Am. J. Hum. Genet. 84(6):718-727(2009)
Zimmermann, F.A., et al. Br. J. Cancer 100(9):1434-1437(2009)
Saada, A., et al. Am. J. Hum. Genet. 82(1):32-38(2008)
Tozlu-Kara, S., et al. J. Mol. Endocrinol. 39(4):305-318(2007)
Karp, C.M., et al. Oncogene 26(12):1780-1788(2007)
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