|Application ||WB, E|
|Calculated MW||128558 Da|
|Antigen Region||675-703 aa|
|Other Names||Ras GTPase-activating protein nGAP, RAS protein activator-like 2, RASAL2, NGAP|
|Target/Specificity||This RASAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 675-703 amino acids from the Central region of human RASAL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RASAL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitory regulator of the Ras-cyclic AMP pathway.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)
Shibui, T., et al. Biotechnol. Lett. 30(12):2037-2043(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Noto, S., et al. FEBS Lett. 441(1):127-131(1998)
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