|Application ||WB, E|
|Other Accession||Q5XI01, Q05CL8, Q4R627, NP_056269.1, NP_057732.2|
|Predicted||Monkey, Mouse, Rat|
|Calculated MW||66899 Da|
|Antigen Region||527-556 aa|
|Other Names||La-related protein 7, La ribonucleoprotein domain family member 7, P-TEFb-interaction protein for 7SK stability, PIP7S, LARP7|
|Target/Specificity||This LARP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-556 amino acids from the C-terminal region of human LARP7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LARP7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.|
|Cellular Location||Nucleus, nucleoplasm|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
LARP7 is a negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Tyagi, M., et al. J. Virol. 84(13):6425-6437(2010)
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Markert, A., et al. EMBO Rep. 9(6):569-575(2008)
Krueger, B.J., et al. Nucleic Acids Res. 36(7):2219-2229(2008)
He, N., et al. Mol. Cell 29(5):588-599(2008)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.