|Application ||WB, E|
|Other Accession||Q5XI01, Q05CL8, Q4R627, NP_056269.1, NP_057732.2|
|Predicted||Monkey, Mouse, Rat|
|Calculated MW||66899 Da|
|Antigen Region||527-556 aa|
|Other Names||La-related protein 7, La ribonucleoprotein domain family member 7, P-TEFb-interaction protein for 7SK stability, PIP7S, LARP7|
|Target/Specificity||This LARP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-556 amino acids from the C-terminal region of human LARP7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LARP7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.|
|Cellular Location||Nucleus, nucleoplasm|
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Provided below are standard protocols that you may find useful for product applications.
LARP7 is a negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Tyagi, M., et al. J. Virol. 84(13):6425-6437(2010)
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Markert, A., et al. EMBO Rep. 9(6):569-575(2008)
Krueger, B.J., et al. Nucleic Acids Res. 36(7):2219-2229(2008)
He, N., et al. Mol. Cell 29(5):588-599(2008)
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