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HBQ1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P09105 |
| Other Accession | NP_005322.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 15508 Da |
| Antigen Region | 1-28 aa |
| Gene ID | 3049 |
|---|---|
| Other Names | Hemoglobin subunit theta-1, Hemoglobin theta-1 chain, Theta-1-globin, HBQ1 |
| Target/Specificity | This HBQ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-28 amino acids from the N-terminal region of human HBQ1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HBQ1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HBQ1 |
|---|
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Provided below are standard protocols that you may find useful for product applications.
Background
Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.
References
De Gobbi, M., et al. Science 312(5777):1215-1217(2006)
Patrinos, G.P., et al. Hum. Mutat. 26(5):399-412(2005)
Daniels, R.J., et al. Hum. Mol. Genet. 10(4):339-352(2001)
Giardina, B., et al. Crit. Rev. Biochem. Mol. Biol. 30(3):165-196(1995)
Kim, J.H., et al. Nucleic Acids Res. 17(14):5687-5700(1989)
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