|Application ||WB, IHC-P, E|
|Calculated MW||15508 Da|
|Antigen Region||1-28 aa|
|Other Names||Hemoglobin subunit theta-1, Hemoglobin theta-1 chain, Theta-1-globin, HBQ1|
|Target/Specificity||This HBQ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-28 amino acids from the N-terminal region of human HBQ1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HBQ1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.
De Gobbi, M., et al. Science 312(5777):1215-1217(2006)
Patrinos, G.P., et al. Hum. Mutat. 26(5):399-412(2005)
Daniels, R.J., et al. Hum. Mol. Genet. 10(4):339-352(2001)
Giardina, B., et al. Crit. Rev. Biochem. Mol. Biol. 30(3):165-196(1995)
Kim, J.H., et al. Nucleic Acids Res. 17(14):5687-5700(1989)
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