|Application ||WB, E|
|Calculated MW||55713 Da|
|Antigen Region||343-371 aa|
|Other Names||GPI mannosyltransferase 2, 241-, GPI mannosyltransferase II, GPI-MT-II, Phosphatidylinositol-glycan biosynthesis class V protein, PIG-V, PIGV|
|Target/Specificity||This PIGV antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-371 amino acids from the C-terminal region of human PIGV.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIGV Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. The biosynthetic pathway of GPI is mediated by sequential addition of sugars and other components to phosphatidylinositol. PIGV adds the second mannose to the GPI core (Kang et al., 2005 [PubMed 15623507]).
Krawitz, P.M., et al. Nat. Genet. 42(10):827-829(2010)
Kang, J.Y., et al. J. Biol. Chem. 280(10):9489-9497(2005)
Fabre, A.L., et al. FEBS J. 272(5):1160-1168(2005)
Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)
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