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TMM70 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TMM70 Antibody (C-term) AP13011b
    TMM70 Antibody (C-term) (Cat. #AP13011b) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the TMM70 antibody detected the TMM70 protein (arrow).
    detail
  • IHC-P - TMM70 Antibody (C-term) AP13011b
    TMM70 Antibody (C-term) (Cat. #AP13011b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TMM70 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q9BUB7
Other Accession NP_060336.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 28969 Da
Antigen Region 231-260 aa
Additional Information
Gene ID 54968
Other Names Transmembrane protein 70, mitochondrial, TMEM70
Target/Specificity This TMM70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the C-terminal region of human TMM70.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTMM70 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM70 (HGNC:26050)
Function Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (PubMed:31652072, PubMed:33753518, PubMed:33359711, PubMed:32275929). Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis (PubMed:33359711, PubMed:18953340, PubMed:20937241, PubMed:31652072). In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies (PubMed:32275929).
Cellular Location Mitochondrion inner membrane; Multi-pass membrane protein. Note=Mostly located within the inner cristae membrane
Tissue Location Lower expressed in the heart than in the liver (at protein level).
Research Areas
Citations (0)
citation

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Background

This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Karasik, D., et al. J. Bone Miner. Res. 25(7):1555-1563(2010)
Honzik, T., et al. Arch. Dis. Child. 95(4):296-301(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 365.00
$ 140.00
Cat# AP13011b
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