TMM70 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
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Primary Accession | Q9BUB7 |
Other Accession | NP_060336.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 28969 Da |
Antigen Region | 231-260 aa |
Gene ID | 54968 |
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Other Names | Transmembrane protein 70, mitochondrial, TMEM70 |
Target/Specificity | This TMM70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the C-terminal region of human TMM70. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TMM70 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TMEM70 (HGNC:26050) |
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Function | Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (PubMed:31652072, PubMed:33753518, PubMed:33359711, PubMed:32275929). Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis (PubMed:33359711, PubMed:18953340, PubMed:20937241, PubMed:31652072). In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies (PubMed:32275929). |
Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein. Note=Mostly located within the inner cristae membrane |
Tissue Location | Lower expressed in the heart than in the liver (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Karasik, D., et al. J. Bone Miner. Res. 25(7):1555-1563(2010)
Honzik, T., et al. Arch. Dis. Child. 95(4):296-301(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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