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> home > Products > Antibodies > Biological Process > Cell Differentiation > ARHGAP22 Antibody (C-term)

ARHGAP22 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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Catalog #	Size	Availability	Price
AP13013b	0.1 mg 400 ul	In Stock	$ 255.00	DISCONTINED INQUIRE CLICK INQUIRE Add to cart
AP13013b-ev20	20 ug 100 ul	In Stock	$ 95.00	DISCONTINED INQUIRE CLICK INQUIRE Add to cart

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ARHGAP22 Antibody (C-term) - Product info
Application	WB Applications Legend: W=Western Blotting IP=Immunoprecipitation IHC-P=Immunohistochemistry (Paraffin) IF-IC=Immunofluorescence (Immunocytochemistry) F=Flow Cytometry
Primary Accession	Q7Z5H3
Other Accession	NP_067049.2
Reactivity	Human
Concentration	0.25 mg/ml
Isotype	Rabbit Ig
Calculated MW	76779 Da
ARHGAP22 Antibody (C-term) - Additional info
Gene ID 58504
Other Names ARHGAP22; RHOGAP2; Rho GTPase-activating protein 22; Rho-type GTPase-activating protein 22
Target/Specificity This ARHGAP22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-633 amino acids from the C-terminal region of human ARHGAP22.
Dilution WB~~1:100~500WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions ARHGAP22 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
ARHGAP22 Antibody (C-term) - Protein Information
Name ARHGAP22
Synonyms RHOGAP2
Function Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity)
Cellular Location Cytoplasm (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity)

ARHGAP22 Antibody (C-term) - Related products

AP13013b: ARHGAP22 Antibody (C-term)

ARHGAP22 Antibody (C-term) - Application data

ARHGAP22 Antibody (C-term) (Cat. #AP13013b) western blot analysis in MDA-MB231,WiDr,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ARHGAP22 antibody detected the ARHGAP22 protein (arrow).

ARHGAP22 Antibody (C-term) - Research Areas

Antibodies Biological Process Cell Differentiation Organ Development Signal Transduction Metabolic Process Primary Metabolic Process Cellular Metabolic Process Cellular Process System Development Macromolecule Metabolic Process Multicellular Organismal Development Anatomical Structure Development Developmental Process Cellular Macromolecule Metabolic Process Anatomical Structure Morphogenesis Vasculature Development Blood Vessel Development Blood Vessel Morphogenesis Angiogenesis Regulation Of Metabolic Process Cellular Developmental Process Regulation Of Cellular Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Biological Regulation Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Biological Process Biosynthetic Process Multicellular Organismal Process Cellular Biosynthetic Process Regulation Of Cellular Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Pathway Panther Angiogenesis

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

ARHGAPs, such as ARHGAP22, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).

REFERENCES

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Dick, D.M., et al. Mol. Psychiatry (2010) In press : Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006) Katoh, M., et al. Int. J. Mol. Med. 14(2):333-338(2004)