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ARHGAP22 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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Ordering Information
Catalog # SizeAvailability Available Date  
AP13013b 400 µl
(40 western blots)
Backorder 4 months
AP13013b-ev 80 µl
(8 western blots)
Backorder 4 months
  • Specification
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ARHGAP22 Antibody (C-term) - Product Information

Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary AccessionQ7Z5H3
Other AccessionNP_067049.2
ReactivityHuman
Isotype Rabbit Ig
Calculated MW 76779 Da

ARHGAP22 Antibody (C-term) - Additional Information

Gene ID 58504
Other Names
ARHGAP22; RHOGAP2; Rho GTPase-activating protein 22; Rho-type GTPase-activating protein 22
Target/Specificity
This ARHGAP22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 604-633 amino acids from the C-terminal region of human ARHGAP22.
Dilution
WB~~1:1000
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
ARHGAP22 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.

ARHGAP22 Antibody (C-term) - Protein Information

Name ARHGAP22
Synonyms RHOGAP2
Function
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).
Cellular Location
Cytoplasm (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity)

ARHGAP22 Antibody (C-term) - Related Products

BP13013b: ARHGAP22 Antibody (C-term) Blocking Peptides

ARHGAP22 Antibody (C-term) - Research Areas

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

ARHGAPs, such as ARHGAP22, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).

REFERENCES

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Dick, D.M., et al. Mol. Psychiatry (2010) In press :
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Katoh, M., et al. Int. J. Mol. Med. 14(2):333-338(2004)