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HERV-FRD Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HERV-FRD Antibody (N-term) AP13018A
    HERV-FRD Antibody (N-term) (Cat. #AP13018a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the HERV-FRD antibody detected the HERV-FRD protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P60508
Other Accession P61556, NP_997465.1
Reactivity Human
Predicted Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 59523 Da
Antigen Region 79-107 aa
Additional Information
Gene ID 405754
Other Names Syncytin-2, Endogenous retrovirus group FRD member 1, Envelope polyprotein, HERV-FRD, HERV-FRD_6p241 provirus ancestral Env polyprotein, Surface protein, SU, Transmembrane protein, TM, ERVFRD-1, ERVFRDE1
Target/Specificity This HERV-FRD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the N-terminal region of human HERV-FRD.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHERV-FRD Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ERVFRDE1
Function This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732).
Cellular Location Virion.
Tissue Location Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea
Research Areas
Citations ( 0 )


Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).


Vargas, A., et al. J. Mol. Biol. 392(2):301-318(2009)
Chen, C.P., et al. Biol. Reprod. 79(5):815-823(2008)
Malassine, A., et al. Retrovirology 5, 6 (2008) :
Mangeney, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(51):20534-20539(2007)
Malassine, A., et al. Placenta 28 (2-3), 185-191 (2007) :

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$ 295.00
$ 99.00
Cat# AP13018A
(40 western blots)
Availability: In Stock
Bulk Size
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