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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Bak Antibody (BH3 Domain Specific)   

Bak Antibody (BH3 Domain Specific)

Purified Rabbit Polyclonal Antibody (Pab)

  • IHC-P - Bak Antibody (BH3 Domain Specific) AP1301a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • WB - Bak Antibody (BH3 Domain Specific) AP1301a
    Bak Antibody (BH3) (Cat. #AP1301a) western blot analysis in Jurkat,MDA-MB453,293 cell line lysates (35ug/lane).This demonstrates the Bak antibody detected the Bak protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16611
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23409 Da
Antigen Region 56-91 aa
Additional Information
Gene ID 578
Other Names Bcl-2 homologous antagonist/killer, Apoptosis regulator BAK, Bcl-2-like protein 7, Bcl2-L-7, BAK1, BAK, BCL2L7, CDN1
Target/Specificity This Bak antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-91 amino acids from human Bak.
Dilution IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBak Antibody (BH3 Domain Specific) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAK1
Synonyms BAK, BCL2L7, CDN1
Function In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.
Cellular Location Mitochondrion membrane; Single-pass membrane protein
Tissue Location Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle
Research Areas
Citations (0)

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BAK belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAK localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.


Cartron, P.F., et al., Mol. Cell. Biol. 23(13):4701-4712 (2003).
Mikhailov, V., et al., J. Biol. Chem. 278(7):5367-5376 (2003).
Werner, A.B., et al., J. Biol. Chem. 277(25):22781-22788 (2002).
Bellosillo, B., et al., Blood 100(5):1810-1816 (2002).
Grutkoski, P.S., et al., Shock 17(1):47-54 (2002).

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$ 295.00
$ 99.00
Cat# AP1301a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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