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MBNL2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MBNL2 Antibody (C-term) AP13023B
    MBNL2 Antibody (C-term) (Cat. #AP13023b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MBNL2 antibody detected the MBNL2 protein (arrow).
  • IHC-P - MBNL2 Antibody (C-term) AP13023B
    MBNL2 Antibody (C-term) (Cat. #AP13023b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MBNL2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - MBNL2 Antibody (C-term) AP13023B
    MBNL2 Antibody (C-term) (Cat. #AP13023b) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5VZF2
Other Accession NP_659002.1, NP_997187.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 40518 Da
Antigen Region 261-290 aa
Additional Information
Gene ID 10150
Other Names Muscleblind-like protein 2, Muscleblind-like protein 1, Muscleblind-like protein-like, Muscleblind-like protein-like 39, MBNL2, MBLL, MBLL39, MLP1
Target/Specificity This MBNL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids from the C-terminal region of human MBNL2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMBNL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBNL2
Synonyms MBLL, MBLL39, MLP1
Function Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).
Cellular Location Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques. Location in the cytoplasm is microtubule-dependent. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts
Tissue Location Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
Citations (0)

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This gene encodes a C3H-type zinc finger protein, which is similar to the Drosophila melanogaster muscleblind B protein. Drosophila muscleblind is a gene required for photoreceptor differentiation. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
He, F., et al. Protein Sci. 18(1):80-91(2009)
Holt, I., et al. Am. J. Pathol. 174(1):216-227(2009)
Paul, S., et al. EMBO J. 25(18):4271-4283(2006)
Adereth, Y., et al. Nat. Cell Biol. 7(12):1240-1247(2005)

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Cat# AP13023B
(40 western blots)
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