|Application ||WB, E|
|Calculated MW||30344 Da|
|Antigen Region||232-260 aa|
|Other Names||Proline synthase co-transcribed bacterial homolog protein, PROSC|
|Target/Specificity||This PROSC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-260 amino acids from the C-terminal region of human PROSC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PROSC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.|
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Provided below are standard protocols that you may find useful for product applications.
PROSC is ubiquitously expressed in human tissues and has been highly conserved among divergent species from bacteria to mammals, suggesting it has an important cellular function. PROSC is likely to be a soluble cytoplasmic protein, but its function remains to be determined. The P. aeruginosa homolog of this novel gene is located upstream of and may be cotranscribed with a known proline biosynthetic gene, hence the human gene was celled PROSC, for 'proline synthetase cotranscribed, bacterial homolog.'
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
Ikegawa, S., et al. J. Hum. Genet. 44(5):337-342(1999)
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