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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   ZFYVE19 Antibody (C-term)   

ZFYVE19 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ZFYVE19 Antibody (C-term) AP13027b
    ZFYVE19 Antibody (C-term) (Cat. #AP13027b) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the ZFYVE19 antibody detected the ZFYVE19 protein (arrow).
  • IHC-P - ZFYVE19 Antibody (C-term) AP13027b
    ZFYVE19 Antibody (C-term) (Cat. #AP13027b)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ZFYVE19 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96K21
Other Accession NP_001070736.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51546 Da
Antigen Region 387-415 aa
Additional Information
Gene ID 84936
Other Names Abscission/NoCut checkpoint regulator, ANCHR, MLL partner containing FYVE domain, Zinc finger FYVE domain-containing protein 19, ZFYVE19, ANCHR, MPFYVE
Target/Specificity This ZFYVE19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-415 amino acids from the C-terminal region of human ZFYVE19.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZFYVE19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZFYVE19
Function Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cleavage furrow. Midbody. Note=Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis (PubMed:24814515).
Tissue Location Detected in brain, heart, skeletal muscle, kidney and liver.
Research Areas
Citations (0)

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Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Chinwalla, V., et al. Oncogene 22(9):1400-1410(2003)

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$ 295.00
$ 99.00
Cat# AP13027b
(40 western blots)
Availability: In Stock
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