|Application ||WB, IHC-P, E|
|Calculated MW||79971 Da|
|Antigen Region||314-343 aa|
|Other Names||Ankyrin repeat domain-containing protein 6, Diversin, ANKRD6, KIAA0957|
|Target/Specificity||This ANKRD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-343 amino acids from the Central region of human ANKRD6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANKRD6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.|
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Provided below are standard protocols that you may find useful for product applications.
ANKRD6 recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals (By similarity).
Haribaskar, R., et al. Biochem. Biophys. Res. Commun. 387(1):212-217(2009)
Miyasaka, K.Y., et al. Proc. Natl. Acad. Sci. U.S.A. 104(27):11274-11279(2007)
Schwarz-Romond, T., et al. Genes Dev. 16(16):2073-2084(2002)
Tissir, F., et al. Dev. Dyn. 224(4):465-469(2002)
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