|Application ||WB, E|
|Other Accession||Q2KIA4, NP_001032671.2, NP_079182.2|
|Calculated MW||37610 Da|
|Antigen Region||147-175 aa|
|Other Names||Stearoyl-CoA desaturase 5, Acyl-CoA-desaturase 4, HSCD5, Stearoyl-CoA 9-desaturase, SCD5, ACOD4, SCD4|
|Target/Specificity||This SCD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the Central region of human SCD5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SCD5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung.|
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Provided below are standard protocols that you may find useful for product applications.
Stearoyl-CoA desaturase (SCD; EC 22.214.171.124) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).
Bailey, S.D., et al. Diabetes Care (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Lengi, A.J., et al. Lipids 42(6):499-508(2007)
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