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AR Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP13058c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13058c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Backgrounds
AR Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | P10275 |
| Other Accession | O97952, NP_001011645.1 |
| Reactivity | Human |
| Predicted | Monkey |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 98989 Da |
AR Antibody (Center) - Additional info | |
| Gene ID 367 | |
| Other Names AR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4 | |
| Target/Specificity This AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-309 amino acids from the Central region of human AR. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AR Antibody (Center) - Protein Information | |
| Name AR | |
| Synonyms DHTR, NR3C4 | |
| Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | |
| Cellular Location Nucleus. Cytoplasm. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1 | |
| Tissue Location Isoform 2 is mainly expressed in heart and skeletal muscle | |
AR Antibody (Center) - Related products
AP2509a: Androgen Receptor (ANDR) Antibody
AP10111c: AR Antibody (Center)
AP13058c: AR Antibody (Center)
AP13255c: AR Antibody (Center)
BP10111c: AR Antibody (Center) Blocking peptide
AR Antibody (Center) - Application data
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AR Antibody (Center) (Cat. #AP13058c) western blot analysis in NCI-H292,NCI-H460 cell line lysates (35ug/lane).This demonstrates the AR antibody detected the AR protein (arrow).
AR Antibody (Center) - Research Areas
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BACKGROUND
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq].
REFERENCES
Shu, S.K., et al. J. Biol. Chem. 285(43):33045-33053(2010) Nedelsky, N.B., et al. Neuron 67(6):936-952(2010) Panda, B., et al. Gynecol. Endocrinol. (2010) In press : Schneider, G., et al. Am J Geriatr Psychiatry (2010) In press : Guadalupe-Grau, A., et al. PLoS ONE 5 (7), E11529 (2010) :
