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LZTS1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - LZTS1 Antibody (N-term) AP13069a
    LZTS1 Antibody (N-term) (Cat. #AP13069a) western blot analysis in A2058 cell line and mouse brain tissue lysates (35ug/lane).This demonstrates the LZTS1 antibody detected the LZTS1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y250
Other Accession NP_066300.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 66613 Da
Antigen Region 77-105 aa
Additional Information
Gene ID 11178
Other Names Leucine zipper putative tumor suppressor 1, F37/esophageal cancer-related gene-coding leucine-zipper motif, Fez1, LZTS1, FEZ1
Target/Specificity This LZTS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the N-terminal region of human LZTS1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLZTS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LZTS1
Synonyms FEZ1
Function Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.
Cellular Location Cytoplasm. Cell membrane. Cell projection, dendritic spine Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse Note=Associated with the plasma membrane and with microtubules Detected in dendritic spines, especially in the postsynaptic density (By similarity).
Tissue Location Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines
Research Areas
Citations (0)

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This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.


Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Chattopadhyay, I., et al. Mutat. Res. 696(2):130-138(2010)
Califano, D., et al. J. Cell. Physiol. 222(2):382-386(2010)
Shyn, S.I., et al. Mol. Psychiatry (2009) In press :
Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)

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$ 295.00
$ 99.00
Cat# AP13069a
(40 western blots)
Availability: In Stock
Bulk Size
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