|Application ||WB, E|
|Calculated MW||158554 Da|
|Antigen Region||204-232 aa|
|Other Names||ATPase family AAA domain-containing protein 2, AAA nuclear coregulator cancer-associated protein, ANCCA, ATAD2|
|Target/Specificity||This ATAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-232 amino acids from the N-terminal region of human ATAD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATAD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.|
|Tissue Location||Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain.
Revenko, A.S., et al. Mol. Cell. Biol. 30(22):5260-5272(2010)
Ciro, M., et al. Cancer Res. 69(21):8491-8498(2009)
Zou, J.X., et al. Cancer Res. 69(8):3339-3346(2009)
Zou, J.X., et al. Proc. Natl. Acad. Sci. U.S.A. 104(46):18067-18072(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.