|Application ||WB, E|
|Calculated MW||158554 Da|
|Antigen Region||204-232 aa|
|Other Names||ATPase family AAA domain-containing protein 2, AAA nuclear coregulator cancer-associated protein, ANCCA, ATAD2|
|Target/Specificity||This ATAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-232 amino acids from the N-terminal region of human ATAD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATAD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.|
|Tissue Location||Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors|
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Provided below are standard protocols that you may find useful for product applications.
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain.
Revenko, A.S., et al. Mol. Cell. Biol. 30(22):5260-5272(2010)
Ciro, M., et al. Cancer Res. 69(21):8491-8498(2009)
Zou, J.X., et al. Cancer Res. 69(8):3339-3346(2009)
Zou, J.X., et al. Proc. Natl. Acad. Sci. U.S.A. 104(46):18067-18072(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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