|Application ||WB, E|
|Other Accession||NP_006424.2, NP_036615.2|
|Calculated MW||16374 Da|
|Antigen Region||14-42 aa|
|Other Names||Granulysin, Lymphokine LAG-2, Protein NKG5, T-cell activation protein 519, GNLY, LAG2, NKG5, TLA519|
|Target/Specificity||This GNLY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human GNLY.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GNLY Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LAG2, NKG5, TLA519|
|Function||Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.|
|Cellular Location||Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation|
|Tissue Location||Expressed in natural killer and T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
Xing, J., et al. J. Immunol. 185(9):5074-5081(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Yang, C., et al. Int. J. Tuberc. Lung Dis. 13(11):1360-1366(2009)
Hogg, A.E., et al. J. Leukoc. Biol. 86(5):1191-1203(2009)
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