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MBNL3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MBNL3 Antibody (Center) AP13080c
    MBNL3 Antibody (Center) (Cat. #AP13080c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MBNL3 antibody detected the MBNL3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NUK0
Other Accession NP_001164174.1, NP_001164173.1, NP_597846.1, NP_001164175.1, NP_001164172.1, NP_060858.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38532 Da
Antigen Region 251-280 aa
Additional Information
Gene ID 55796
Other Names Muscleblind-like protein 3, Cys3His CCG1-required protein, Muscleblind-like X-linked protein, Protein HCHCR, MBNL3, CHCR, MBLX39, MBXL
Target/Specificity This MBNL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-280 amino acids from the Central region of human MBNL3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMBNL3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBNL3
Synonyms CHCR, MBLX39, MBXL
Function Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
Cellular Location Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts
Tissue Location Highly expressed in the placenta.
Research Areas
Citations (0)

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This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described.


Holt, I., et al. Am. J. Pathol. 174(1):216-227(2009)
Self, J.E., et al. Mol. Vis. 12, 1211-1216 (2006) :
Ho, T.H., et al. EMBO J. 23(15):3103-3112(2004)
Squillace, R.M., et al. Dev. Biol. 250(1):218-230(2002)
Fardaei, M., et al. Hum. Mol. Genet. 11(7):805-814(2002)

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Cat# AP13080c
(40 western blots)
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