|Application ||WB, IHC-P, E|
|Other Accession||Q8CFS6, NP_598004.1|
|Calculated MW||62459 Da|
|Antigen Region||478-507 aa|
|Other Names||Potassium voltage-gated channel subfamily V member 2, Voltage-gated potassium channel subunit Kv82, KCNV2|
|Target/Specificity||This KCNV2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 478-507 amino acids from the C-terminal region of human KCNV2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNV2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1|
|Tissue Location||Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon|
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Provided below are standard protocols that you may find useful for product applications.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues.
Robson, A.G., et al. Retina (Philadelphia, Pa.) 30(1):51-62(2010)
Ben Salah, S., et al. Am. J. Ophthalmol. 145(6):1099-1106(2008)
Wissinger, B., et al. Invest. Ophthalmol. Vis. Sci. 49(2):751-757(2008)
Thiagalingam, S., et al. Ophthalmic Genet. 28(3):135-142(2007)
Balijepalli, R.C., et al. Channels (Austin) 1(4):263-272(2007)
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