|Application ||WB, IHC-P, E|
|Other Accession||Q9QXM0, Q4R2Y9, Q5EA42, NP_690888.1|
|Predicted||Bovine, Monkey, Mouse|
|Calculated MW||48315 Da|
|Antigen Region||263-292 aa|
|Other Names||Abhydrolase domain-containing protein 2, 311-, Lung alpha/beta hydrolase 2, Protein PHPS1-2, ABHD2, LABH2|
|Target/Specificity||This ABHD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the Central region of human ABHD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABHD2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).|
|Cellular Location||Cell projection, cilium, flagellum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Present in sperm (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq].
Giambra, V., et al. J. Immunol. 183(12):8280-8285(2009)
Miyata, K., et al. Biochem. Biophys. Res. Commun. 365(2):207-213(2008)
Edgar, A.J., et al. Biochem. Biophys. Res. Commun. 292(3):617-625(2002)
Rapiejko, P.J., et al. Nucleic Acids Res. 16 (17), 8721 (1988) :
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