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ABHD2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ABHD2 Antibody (Center) AP13083c
    ABHD2 Antibody (Center) (Cat. #AP13083c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ABHD2 antibody detected the ABHD2 protein (arrow).
  • IHC-P - ABHD2 Antibody (Center) AP13083c
    ABHD2 Antibody (Center) (Cat. #AP13083c)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ABHD2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P08910
Other Accession Q9QXM0, Q4R2Y9, Q5EA42, NP_690888.1
Reactivity Human
Predicted Bovine, Monkey, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 48315 Da
Antigen Region 263-292 aa
Additional Information
Gene ID 11057
Other Names Abhydrolase domain-containing protein 2, 311-, Lung alpha/beta hydrolase 2, Protein PHPS1-2, ABHD2, LABH2
Target/Specificity This ABHD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the Central region of human ABHD2.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsABHD2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABHD2 (HGNC:18717)
Function Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).
Cellular Location Cell projection, cilium, flagellum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein
Tissue Location Present in sperm (at protein level).
Citations (0)

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Background

This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq].

References

Giambra, V., et al. J. Immunol. 183(12):8280-8285(2009)
Miyata, K., et al. Biochem. Biophys. Res. Commun. 365(2):207-213(2008)
Edgar, A.J., et al. Biochem. Biophys. Res. Commun. 292(3):617-625(2002)
Rapiejko, P.J., et al. Nucleic Acids Res. 16 (17), 8721 (1988) :

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$ 295.00
$ 99.00
Cat# AP13083c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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