|Application ||WB, IHC-P, E|
|Other Accession||Q7TT45, Q9NQL2, Q99K70, NP_071440.1|
|Calculated MW||44224 Da|
|Antigen Region||169-198 aa|
|Other Names||Ras-related GTP-binding protein C, Rag C, RagC, GTPase-interacting protein 2, TIB929, RRAGC (HGNC:19902)|
|Target/Specificity||This RRAGC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-198 amino acids from the Central region of human RRAGC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RRAGC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.|
|Cellular Location||Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942)|
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Provided below are standard protocols that you may find useful for product applications.
RRAGC is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.
Sekiguchi, T., et al. J. Biol. Chem. 279(9):8343-8350(2004)
Sekiguchi, T., et al. J. Biol. Chem. 276(10):7246-7257(2001)
Horwitz, M.S. Virology 279(1):1-8(2001)
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