|Application ||WB, IHC-P, E|
|Calculated MW||31642 Da|
|Antigen Region||248-277 aa|
|Other Names||Dexamethasone-induced Ras-related protein 1, Activator of G-protein signaling 1, RASD1, AGS1, DEXRAS1|
|Target/Specificity||This RASD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-277 amino acids from the C-terminal region of human RASD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RASD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region. Nucleus|
|Tissue Location||Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a Ras-related protein that is stimulated by dexamethasone. The exact function of this gene is unknown, but it may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. In addition, studies of a similar rat protein suggest that it functions as as a novel physiologic nitric oxide (NO) effector. The gene product belongs to the Ras superfamily of small GTPases.
Nojima, M., et al. Clin. Cancer Res. 15(13):4356-4364(2009)
Lau, K.F., et al. J. Biol. Chem. 283(50):34728-34737(2008)
Attarzadeh-Yazdi, G., et al. Neurochem. Res. 33(4):609-613(2008)
Cheng, H.Y., et al. J. Neurosci. 26(50):12984-12995(2006)
Nguyen, C.H., et al. Mol. Pharmacol. 69(5):1763-1771(2006)
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