|Application ||WB, E|
|Other Accession||Q9D2H6, NP_003101.3|
|Calculated MW||64900 Da|
|Antigen Region||498-526 aa|
|Other Names||Transcription factor Sp2, SP2, KIAA0048|
|Target/Specificity||This SP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-526 amino acids from the C-terminal region of human SP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.
Ito, H., et al. Biochim. Biophys. Acta 1789 (11-12), 681-690 (2009) :
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Letourneur, M., et al. Mol. Immunol. 46 (11-12), 2151-2160 (2009) :
Sun, J.M., et al. J. Biol. Chem. 282(45):33227-33236(2007)
Das, A., et al. J. Biol. Chem. 281(51):39105-39113(2006)
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