|Application ||WB, IHC-P, E|
|Other Accession||Q9WU28, Q8HYI9, NP_002615.2|
|Calculated MW||17328 Da|
|Antigen Region||79-108 aa|
|Other Names||Prefoldin subunit 5, C-Myc-binding protein Mm-1, Myc modulator 1, PFDN5, MM1, PFD5|
|Target/Specificity||This PFDN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-108 amino acids from the Central region of human PFDN5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PFDN5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.|
|Cellular Location||Isoform 1: Nucleus. Isoform 3: Nucleus.|
|Tissue Location||Highly expressed in pancreas and skeletal muscle and moderately in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq].
Ma, H.C., et al. J. Biomed. Sci. 15(4):417-425(2008)
Yoshida, T., et al. Exp. Cell Res. 314(6):1217-1228(2008)
Lubyova, B., et al. J. Biol. Chem. 282(44):31944-31953(2007)
Hagio, Y., et al. J. Cell. Biochem. 97(1):145-155(2006)
Bruneel, A., et al. Proteomics 5(15):3876-3884(2005)
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