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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   PYDC1 Antibody (Center)   

PYDC1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PYDC1 Antibody (Center) AP13124C
    PYDC1 Antibody (Center) (Cat. #AP13124c) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PYDC1 antibody detected the PYDC1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WXC3
Other Accession NP_690865.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 10107 Da
Antigen Region 13-42 aa
Additional Information
Gene ID 260434
Other Names Pyrin domain-containing protein 1, PAAD-only protein 1, Pyrin-only protein 1, PYDC1, ASC2, ASCI, POP1, PYC1
Target/Specificity This PYDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the Central region of human PYDC1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPYDC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PYDC1 (HGNC:30261)
Function Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
Cellular Location Cytoplasm. Note=Recruited to specks formed by PYCARD within the cytoplasm
Tissue Location Predominantly expressed in monocytes, macrophages and granulocytes.
Research Areas
Citations (0)

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PYDC1 associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.


Son, Y.L., et al. Biochem. J. 410(2):319-330(2008)
Natarajan, A., et al. J. Biol. Chem. 281(42):31863-31875(2006)
Espejo, F., et al. Biochem. Biophys. Res. Commun. 340(3):860-864(2006)
Stehlik, C., et al. Biochem. J. 373 (PT 1), 101-113 (2003) :
Pawlowski, K., et al. Trends Biochem. Sci. 26(2):85-87(2001)

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$ 295.00
$ 99.00
Cat# AP13124C
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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