|Application ||WB, E|
|Calculated MW||10107 Da|
|Antigen Region||13-42 aa|
|Other Names||Pyrin domain-containing protein 1, PAAD-only protein 1, Pyrin-only protein 1, PYDC1, ASC2, ASCI, POP1, PYC1|
|Target/Specificity||This PYDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the Central region of human PYDC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PYDC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.|
|Cellular Location||Cytoplasm. Note=Recruited to specks formed by PYCARD within the cytoplasm|
|Tissue Location||Predominantly expressed in monocytes, macrophages and granulocytes.|
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Provided below are standard protocols that you may find useful for product applications.
PYDC1 associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
Son, Y.L., et al. Biochem. J. 410(2):319-330(2008)
Natarajan, A., et al. J. Biol. Chem. 281(42):31863-31875(2006)
Espejo, F., et al. Biochem. Biophys. Res. Commun. 340(3):860-864(2006)
Stehlik, C., et al. Biochem. J. 373 (PT 1), 101-113 (2003) :
Pawlowski, K., et al. Trends Biochem. Sci. 26(2):85-87(2001)
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