|Application ||WB, E|
|Calculated MW||15383 Da|
|Antigen Region||8-36 aa|
|Other Names||39S ribosomal protein L41, mitochondrial, L41mt, MRP-L41, 39S ribosomal protein L27 homolog, Bcl-2-interacting mitochondrial ribosomal protein L41, Cell proliferation-inducing gene 3 protein, MRP-L27 homolog, MRPL41, BMRP, MRPL27, RPML27|
|Target/Specificity||This MRPL41 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-36 amino acids from the N-terminal region of human MRPL41.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MRPL41 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BMRP, MRPL27, RPML27|
|Function||Component of the mitochondrial ribosome large subunit (PubMed:25278503, PubMed:25838379). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796).|
|Tissue Location||Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family.
Kim, M.J., et al. Biochem. Biophys. Res. Commun. 338(2):1179-1184(2005)
Yoo, Y.A., et al. Mol. Cell. Biol. 25(15):6603-6616(2005)
Chintharlapalli, S.R., et al. J. Cell. Biochem. 94(3):611-626(2005)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Zhang, Z., et al. Genomics 81(5):468-480(2003)
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