|Application ||WB, IHC-P, E|
|Other Accession||NP_004717.2, NP_001074444.1|
|Calculated MW||71534 Da|
|Antigen Region||153-182 aa|
|Other Names||RalBP1-associated Eps domain-containing protein 2, Partner of RalBP1, RalBP1-interacting protein 2, REPS2, POB1|
|Target/Specificity||This REPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the N-terminal region of human REPS2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||REPS2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in growth factor signaling through its influence on the Ral signaling pathway.|
|Tissue Location||Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. Isoform 2 is down-regulated during progression of prostate cancer|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.
Doolan, P., et al. Tumour Biol. 30(4):200-209(2009) Singhal, S.S., et al. J. Biol. Chem. 283(28):19714-19729(2008) Yadav, S., et al. Biochem. Biophys. Res. Commun. 328(4):1003-1009(2005) Oosterhoff, J.K., et al. Int. J. Cancer 113(4):561-567(2005) Penninkhof, F., et al. Oncogene 23(33):5607-5615(2004)
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