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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HEMGN Antibody (C-term)   

HEMGN Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HEMGN Antibody (C-term) AP13136b
    HEMGN Antibody (C-term) (Cat. #AP13136b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the HEMGN antibody detected the HEMGN protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9BXL5
Other Accession NP_932095.1, NP_060907.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 55341 Da
Antigen Region 420-449 aa
Additional Information
Gene ID 55363
Other Names Hemogen, Erythroid differentiation-associated gene protein, EDAG-1, Hemopoietic gene protein, Negative differentiation regulator protein, HEMGN, EDAG, NDR
Target/Specificity This HEMGN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 420-449 amino acids from the C-terminal region of human HEMGN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHEMGN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HEMGN
Synonyms EDAG, NDR
Function Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
Cellular Location Nucleus.
Tissue Location Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia.
Research Areas
Citations (0)

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Background

HEMGN regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).

References

Ding, Y.L., et al. J. Cell. Biochem. 110(4):866-874(2010)
Moreno, L.M., et al. Hum. Mol. Genet. 18(24):4879-4896(2009)
Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :
Li, C.Y., et al. Biochim. Biophys. Acta 1779(10):606-615(2008)
Ling, B., et al. Oncol. Rep. 18(3):659-664(2007)

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$ 295.00
$ 99.00
Cat# AP13136b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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