|Application ||WB, IHC-P, E|
|Other Accession||NP_002879.2, NP_996846.1|
|Calculated MW||33285 Da|
|Antigen Region||134-163 aa|
|Other Names||Retinoic acid receptor responder protein 1, Phorbol ester-induced gene 1 protein, PERG-1, RAR-responsive protein TIG1, Tazarotene-induced gene 1 protein, RARRES1, PEIG1, TIG1|
|Target/Specificity||This RARRES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the C-terminal region of human RARRES1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RARRES1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.|
|Cellular Location||Membrane; Single-pass type III membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Kwok, W.K., et al. Cancer Genet. Cytogenet. 194(1):58-64(2009)
Ohnishi, S., et al. Cell Prolif. 42(3):309-316(2009)
Son, M.S., et al. Oncol. Res. 17 (11-12), 571-580 (2009) :
Shutoh, M., et al. Cancer 104(8):1609-1619(2005)
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