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PACS2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q86VP3 |
| Other Accession | NP_001094383.1, NP_056012.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 97702 Da |
| Antigen Region | 642-671 aa |
| Gene ID | 23241 |
|---|---|
| Other Names | Phosphofurin acidic cluster sorting protein 2, PACS-2, PACS1-like protein, PACS2, KIAA0602, PACS1L |
| Target/Specificity | This PACS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 642-671 amino acids from the C-terminal region of human PACS2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PACS2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PACS2 (HGNC:23794) |
|---|---|
| Synonyms | KIAA0602, PACS1L |
| Function | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. |
| Cellular Location | Endoplasmic reticulum. Mitochondrion |
| Tissue Location | Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
References
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Aslan, J.E., et al. Mol. Cell 34(4):497-509(2009)
Myhill, N., et al. Mol. Biol. Cell 19(7):2777-2788(2008)
Atkins, K.M., et al. J. Biol. Chem. 283(17):11772-11784(2008)
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