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PLS1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q14651 |
| Other Accession | NP_001165783.1, NP_001138791.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 70253 Da |
| Antigen Region | 550-579 aa |
| Gene ID | 5357 |
|---|---|
| Other Names | Plastin-1, Intestine-specific plastin, I-plastin, PLS1 |
| Target/Specificity | This PLS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 550-579 amino acids from the C-terminal region of human PLS1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLS1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLS1 |
|---|---|
| Function | Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q3V0K9}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q3V0K9} |
| Tissue Location | In small intestine, colon, and kidney; relatively lower levels of expression are detected in the lung and stomach |
Provided below are standard protocols that you may find useful for product applications.
Background
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.
References
Chafel, M.M., et al. Dev. Dyn. 203(2):141-151(1995)
Lin, C.S., et al. Mol. Cell. Biol. 14(4):2457-2467(1994)
Shibata, M., et al. J. Leukoc. Biol. 54(1):10-16(1993)
Lin, C.S., et al. J. Biol. Chem. 268(4):2781-2792(1993)
Zu, Y., et al. Biochemistry 29(4):1055-1062(1990)
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