|Application ||WB, E|
|Calculated MW||16762 Da|
|Antigen Region||27-55 aa|
|Other Names||Cytochrome c oxidase subunit 5A, mitochondrial, Cytochrome c oxidase polypeptide Va, COX5A|
|Target/Specificity||This COX5A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-55 amino acids from the N-terminal region of human COX5A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COX5A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.|
|Cellular Location||Mitochondrion inner membrane.|
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Provided below are standard protocols that you may find useful for product applications.
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq].
Chen, Z.X., et al. Cell Death Differ. 17(3):408-420(2010)
Fornuskova, D., et al. Biochem. J. 428(3):363-374(2010)
Uddin, M., et al. BMC Evol. Biol. 8, 8 (2008) :
Williams, S.L., et al. J. Biol. Chem. 279(9):7462-7469(2004)
Hofmann, S., et al. Cytogenet. Cell Genet. 83 (3-4), 226-227 (1998) :
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