|Application ||IHC-P, WB, E|
|Other Accession||Q60HC1, NP_068839.1|
|Calculated MW||30338 Da|
|Antigen Region||218-247 aa|
|Other Names||Integral membrane protein 2B, Immature BRI2, imBRI2, Protein E25B, Transmembrane protein BRI, Bri, BRI2, membrane form, Mature BRI2, mBRI2, BRI2 intracellular domain, BRI2 ICD, BRI2C, soluble form, Bri23 peptide, Bri2-23, ABri23, C-terminal peptide, P23 peptide, ITM2B, BRI, BRI2|
|Target/Specificity||This ITM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the C-terminal region of human ITM2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ITM2B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites. Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.|
|Cellular Location||Integral membrane protein 2B: Golgi apparatus membrane; Single-pass type II membrane protein. Note=Immature BRI2 (imBRI2) is cleaved by furin in the Golgi into mBRI2 and a Bri23 peptide mBRI2 is transported to the plasma membrane and Bri23 peptide is secreted Bri23 peptide: Secreted. Note=Detected in the cerebral spinal fluid (CSF).|
|Tissue Location||Ubiquitous. Expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
Peng, S., et al. Biochem. Biophys. Res. Commun. 393(3):356-361(2010)
Matsuda, S., et al. J. Biol. Chem. 284(23):15815-15825(2009)
Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :
Tsachaki, M., et al. Biotechnol J 3(12):1548-1554(2008)
Kim, J., et al. J. Neurosci. 28(23):6030-6036(2008)
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