|Application ||WB, E|
|Other Accession||P11246, P18605, NP_001153645.1, NP_001153642.1, NP_000653.3, NP_001153643.1, NP_001153644.1|
|Calculated MW||33899 Da|
|Antigen Region||102-130 aa|
|Other Names||Arylamine N-acetyltransferase 1, Arylamide acetylase 1, Monomorphic arylamine N-acetyltransferase, MNAT, N-acetyltransferase type 1, NAT-1, NAT1, AAC1|
|Target/Specificity||This NAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the Central region of human NAT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NAT1 Antibody (center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human geneome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Minchin, R.F., et al. Int. J. Biochem. Cell Biol. 39(11):1999-2005(2007)
Barker, D.F., et al. Pharmacogenet. Genomics 16(7):515-525(2006)
Boukouvala, S., et al. Basic Clin. Pharmacol. Toxicol. 96(5):343-351(2005)
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