|Application ||WB, IHC-P, FC, E|
|Other Accession||NP_872621.1, NP_001133.1|
|Calculated MW||21603 Da|
|Antigen Region||17-46 aa|
|Other Names||Amelogenin, X isoform, AMELX, AMG, AMGX|
|Target/Specificity||This AMELX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of human AMELX.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AMELX Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Almqvist, S., et al. J Mater Sci Mater Med 21(3):947-954(2010)
Lee, S.K., et al. J. Dent. Res. 89(1):46-50(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Tomas, C., et al. Forensic Sci Int Genet 3(1):1-6(2008)
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