|Application ||WB, IHC-P, FC, E|
|Other Accession||Q5PPM8, Q3TWL2, Q4R6W2, NP_001094284.1, NP_653169.2|
|Predicted||Monkey, Mouse, Rat|
|Calculated MW||29470 Da|
|Antigen Region||183-211 aa|
|Other Names||Type 1 phosphatidylinositol 4, 5-bisphosphate 4-phosphatase, Type 1 PtdIns-4, 5-P2 4-Ptase, PtdIns-4, 5-P2 4-Ptase I, Transmembrane protein 55B, TMEM55B, C14orf9|
|Target/Specificity||This TM55B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-211 amino acids from the C-terminal region of human TM55B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TM55B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate.|
|Cellular Location||Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).
Zou, J., et al. Proc. Natl. Acad. Sci. U.S.A. 104(43):16834-16839(2007)
Ungewickell, A., et al. Proc. Natl. Acad. Sci. U.S.A. 102(52):18854-18859(2005)
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