|Application ||WB, IHC-P, E|
|Calculated MW||23548 Da|
|Antigen Region||58-86 aa|
|Other Names||Melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2, MRAP2, C6orf117|
|Target/Specificity||This MRAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human MRAP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MRAP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.|
|Cellular Location||Cell membrane; Single-pass membrane protein Endoplasmic reticulum membrane; Single-pass membrane protein Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context|
|Tissue Location||Expressed in the adrenal gland and brain. Not expressed in other tissues.|
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Provided below are standard protocols that you may find useful for product applications.
The specific function of this protein remains unknown.
Sebag, J.A., et al. Sci Signal 3 (116), RA28 (2010) :
Chan, L.F., et al. Proc. Natl. Acad. Sci. U.S.A. 106(15):6146-6151(2009)
Sebag, J.A., et al. J. Biol. Chem. 284(1):610-618(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Metherell, L.A., et al. Nat. Genet. 37(2):166-170(2005)
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