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MRAP2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MRAP2 Antibody (Center) AP13187c
    MRAP2 Antibody (Center) (Cat. #AP13187c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MRAP2 antibody detected the MRAP2 protein (arrow).
  • IHC-P - MRAP2 Antibody (Center) AP13187c
    MRAP2 Antibody (Center) (Cat. #AP13187c)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MRAP2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96G30
Other Accession NP_612418.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23548 Da
Antigen Region 58-86 aa
Additional Information
Gene ID 112609
Other Names Melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2, MRAP2, C6orf117
Target/Specificity This MRAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human MRAP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMRAP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MRAP2
Synonyms C6orf117
Function Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
Cellular Location Cell membrane; Single-pass membrane protein Endoplasmic reticulum membrane; Single-pass membrane protein Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context
Tissue Location Expressed in the adrenal gland and brain. Not expressed in other tissues.
Research Areas
Citations (0)

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The specific function of this protein remains unknown.


Sebag, J.A., et al. Sci Signal 3 (116), RA28 (2010) :
Chan, L.F., et al. Proc. Natl. Acad. Sci. U.S.A. 106(15):6146-6151(2009)
Sebag, J.A., et al. J. Biol. Chem. 284(1):610-618(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Metherell, L.A., et al. Nat. Genet. 37(2):166-170(2005)

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$ 295.00
$ 99.00
Cat# AP13187c
(40 western blots)
Availability: In Stock
Bulk Size
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