|Application ||WB, IHC-P, E|
|Calculated MW||23548 Da|
|Antigen Region||58-86 aa|
|Other Names||Melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2, MRAP2, C6orf117|
|Target/Specificity||This MRAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human MRAP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MRAP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.|
|Cellular Location||Cell membrane; Single-pass membrane protein Endoplasmic reticulum membrane; Single-pass membrane protein Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context|
|Tissue Location||Expressed in the adrenal gland and brain. Not expressed in other tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The specific function of this protein remains unknown.
Sebag, J.A., et al. Sci Signal 3 (116), RA28 (2010) :
Chan, L.F., et al. Proc. Natl. Acad. Sci. U.S.A. 106(15):6146-6151(2009)
Sebag, J.A., et al. J. Biol. Chem. 284(1):610-618(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Metherell, L.A., et al. Nat. Genet. 37(2):166-170(2005)
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