|Application ||WB, IHC-P, E|
|Calculated MW||74892 Da|
|Antigen Region||508-537 aa|
|Other Names||FYVE, RhoGEF and PH domain-containing protein 2, Zinc finger FYVE domain-containing protein 4, FGD2, ZFYVE4|
|Target/Specificity||This FGD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-537 amino acids from the C-terminal region of human FGD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FGD2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm. Nucleus. Early endosome. Early endosome membrane. Cell projection, ruffle membrane. Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides.|
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Provided below are standard protocols that you may find useful for product applications.
FGD2 activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).
Huber, C., et al. J. Biol. Chem. 283(49):34002-34012(2008)
Delague, V., et al. Am. J. Hum. Genet. 81(1):1-16(2007)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Rabizadeh, S., et al. Cytokine Growth Factor Rev. 14 (3-4), 225-239 (2003) :
Salehi, A.H., et al. J. Biol. Chem. 277(50):48043-48050(2002)
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